REGULATION OF THE ENDOCRINE STRESS RESPONSE AND THE MODULATING EFFECTS OF SEX STEROIDS IN ZEBRAFISH (Danio rerio)

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REGULATION OF THE ENDOCRINE STRESS RESPONSE AND THE MODULATING EFFECTS OF SEX STEROIDS IN ZEBRAFISH (Danio rerio)

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dc.contributor.advisor Van Der Kraak, Glen
dc.contributor.advisor Bernier, Nicholas J.
dc.contributor.author Fuzzen, Meghan
dc.date 2010-03-08
dc.date.accessioned 2010-04-22T19:16:54Z
dc.date.available 2010-04-22T19:16:54Z
dc.date.issued 2010-04-22T19:16:54Z
dc.identifier.uri http://hdl.handle.net/10214/2145
dc.description.abstract The purpose of this study was to characterize the endocrine stress response of zebrafish (Danio rerio) and to test if this response is modified by sex or the major sex steroids 17β-estradiol (E2) and 11-ketotestosterone (11KT). A standardized stress of having zebrafish swim in a beaker of stirring water resulted in rapid and transient changes in whole-body cortisol. While the cortisol response of males and females were comparable, exposure to E2 (100 ng/L) for 48 h inhibited the cortisol response of males and exposure to 11KT (100ng/L) for 48 h stimulated the cortisol response of females. The inhibitory actions of E2 were mediated in part by decreases in corticotropin releasing factor (crf) expression and decreases in the synthesis of cortisol by interrenal tissue. This research adds to the increasing knowledge of zebrafish physiology and will be useful for future studies concerning the endocrine stress response in fish. en
dc.language.iso en en
dc.subject 11-ketotestosterone en
dc.subject estradiol en
dc.subject HPI en
dc.subject zebrafish en
dc.subject cortisol en
dc.subject stress en
dc.subject endocrine en
dc.title REGULATION OF THE ENDOCRINE STRESS RESPONSE AND THE MODULATING EFFECTS OF SEX STEROIDS IN ZEBRAFISH (Danio rerio) en
dc.type Thesis en
dc.degree.programme Integrative Biology en
dc.degree.name Master of Science en
dc.degree.department Department of Integrative Biology en


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