Toxicity of human pharmaceuticals and personal care products to Benthic Invertebrates

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Toxicity of human pharmaceuticals and personal care products to Benthic Invertebrates

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dc.contributor.author Dussault, Eve B.
dc.contributor.author Balakrishnan, Vimal K.
dc.contributor.author Sverko, Ed
dc.contributor.author Solomon, Keith R.
dc.contributor.author Sibley, Paul K.
dc.date.accessioned 2011-09-07T02:26:44Z
dc.date.available 2011-09-07T02:26:44Z
dc.date.issued 2008
dc.identifier.citation Dussault, E.B., Balakrishnan, V.K., Sverko, E., Solomon, K.R., and Sibley, P.K. "Toxicity of human pharmaceuticals and personal care products to Benthic Invertebrates." Environmental Toxicology and Chemistry 27.2 (2008): 425-432
dc.identifier.uri http://hdl.handle.net/10214/2962
dc.description.abstract Despite concerns about potential risks associated with the presence of pharmaceuticals and personal care products(PPCPs) in the environment, few toxicological data address the effects of these compounds. In aquatic systems, which often represent the final repository for PPCPs, increasing toxicological information regarding aquatic biota is improving our capacity to assess potential risks. However, responses of key biota, such as benthic invertebrates, have not been investigated as widely. In the present study, we examined the toxicity of four PPCPs—the lipid regulator atorvastatin (ATO), the antiepileptic drug carbamazepine (CBZ), the synthetic hormone 17 -ethinylestradiol (EE2), and the antimicrobial triclosan (TCS)—to the midge Chironomus tentans and the freshwater amphipod Hyalella azteca in 10-d waterborne exposures. The toxicity of the four compounds varied between 0.20 and 47.3 mg/L (median lethal concentration), with a relative toxicity ranking of TCS EE2 ATO CBZ. Hyalella azteca was more sensitive than C. tentans to these compounds. The toxicity data were used in a hazard quotient approach to evaluate the risk posed by the four PPCPs to benthic invertebrates and other aquatic organisms. For each compound, a hazard quotient was calculated by dividing the lowest toxicity value by the highest exposure value found in the literature, to which an uncertainty factor was applied. With hazard quotients of 3.55 to 11.5, we conclude that potential risks exist toward benthic invertebrates for the toxicity of TCS and CBZ and that further investigations of these compounds are required to characterize more completely the risks to benthic organisms. In contrast, our data also indicate that considering the low concentrations currently detected in the environment, ATO and EE2 pose negligible risks to benthic invertebrates.
dc.language.iso en en_US
dc.publisher Environmental Toxicology and Chemistry en_US
dc.subject Benthic invertebrates en_US
dc.subject pharmaceuticals en_US
dc.subject personal care products en_US
dc.subject Toxicity en_US
dc.title Toxicity of human pharmaceuticals and personal care products to Benthic Invertebrates en_US
dc.type Article en_US


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