Saturated and monounsaturated fatty acids differentially regulate adipokine gene expression and are associated with systemic C-Reactive Protein levels.

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Saturated and monounsaturated fatty acids differentially regulate adipokine gene expression and are associated with systemic C-Reactive Protein levels.

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dc.contributor.advisor Mutch, David M
dc.contributor.author Stryjecki, Carolina
dc.date 2011-08-25
dc.date.accessioned 2011-09-14T14:51:27Z
dc.date.available 2011-09-14T14:51:27Z
dc.date.issued 2011-09-14
dc.identifier.uri http://hdl.handle.net/10214/2990
dc.description.abstract This thesis investigates the contributions of fatty acids (FA) to adipokine dysregulation and inflammation. Differentiated 3T3-L1 adipocytes were treated with palmitic, stearic, palmitoleic, and oleic acids and changes in adipokine gene expression were measured. Here it was determined that saturated FA (SFA) increased the expression of RANTES and monounsaturated FA (MUFA) decreased the expression of RANTES and IL-6; demonstrating that FA differentially regulate adipokine expression. Relationships between plasma levels of SFA, MUFA and C-reactive protein (CRP) were also identified in a human observational study, further demonstrating the link between FA and inflammation Moreover, an association was also found between stearoyl-CoA desaturase 1 (SCD1) activity and CRP, demonstrating that SCD1 activity contributes to the inflammatory state. Genetic variation in SCD1 was also found to alter plasma FA and CRP levels, thus contributing to systemic inflammation. Taken together, these results demonstrate that SFA and MUFA influence adipokine dysregulation and systemic inflammation. en_US
dc.language.iso en en_US
dc.subject inflammation en_US
dc.subject fatty acids en_US
dc.subject adipokines en_US
dc.subject stearoyl-CoA desaturase 1 en_US
dc.subject obesity en_US
dc.title Saturated and monounsaturated fatty acids differentially regulate adipokine gene expression and are associated with systemic C-Reactive Protein levels. en_US
dc.type Thesis en_US
dc.degree.programme Human Health and Nutritional Sciences en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Human Health and Nutritional Sciences en_US


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