The influence of chronic, systemic inflammation in the progression of epithelial ovarian cancer

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The influence of chronic, systemic inflammation in the progression of epithelial ovarian cancer

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dc.contributor.advisor Petrik, Jim
dc.contributor.author Kerr, Amanda
dc.date 2012-08-20
dc.date.accessioned 2012-08-28T15:32:27Z
dc.date.available 2012-08-28T15:32:27Z
dc.date.issued 2012-08-28
dc.identifier.uri http://hdl.handle.net/10214/3881
dc.description.abstract Epidemiological studies have described a link between chronic inflammatory conditions, such as diabetes or obesity, and EOC suggesting that systemic inflammation may increase the risk of the disease. The purpose of this study was to identify the impact of prolonged exposure to low-grade inflammation on EOC tumorigenicity. We hypothesized that exposure to this inflammation would accelerate ovarian tumor growth. In vitro, normal and transformed ovarian epithelial cells had limited responsiveness to inflammatory cytokines. In vivo, LPS-induced low-grade chronic systemic inflammation accelerated EOC progression primarily through enhanced angiogenesis. Evaluation of the relationships between chronic systemic inflammation and EOC may provide a role for anti-inflammatory treatment in combinational EOC therapies. Additionally, as the rate of metabolic disorders increases in the Western world the results from this work may facilitate the advancement of complimentary therapeutic interventions for other cancers that are influenced by inflammation. en_US
dc.language.iso en en_US
dc.subject ovarian cancer en_US
dc.subject inflammation en_US
dc.subject cancer en_US
dc.subject ovarian surface epithelium en_US
dc.title The influence of chronic, systemic inflammation in the progression of epithelial ovarian cancer en_US
dc.type Thesis en_US
dc.degree.programme Biomedical Sciences en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Biomedical Sciences en_US


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